Poetry Feet Flashcard

Poetry Feet

Spanish Expressions Using the Verb Estar

Spanish Expressions Using the Verb Estar As one of the verbs meaning to be, estar is used constantly in Spanish to refer to peoples emotions as well as the status of things and persons. Although there are many times estar isnt translated as to be, usually its use is straightforward for English speakers. Estar also finds its way into numerous idiomatic expressions whose meaning may not be obvious at first. Following are some of the most common and/or useful of them, along with sample sentences taken from contemporary writing. Appropriate translations can vary, depending on the context. Spanish Expressions Using Estar dà ³nde estamos (an expression of amazement or disgust at what is being witnessed).  ¿Dà ³nde estamos?  ¡No lo puedo creer! Whats going on here? I cant believe it! estar a gusto (to be comfortable). Estoy a gusto en mi trabajo. I am comfortable with my job. estar al caer (to be on the verge of arriving). El Nexus 5 est al caer, y podrà ­a costar 399 dà ³lares. The Nexus 5 is almost here, and it could cost $399. estar al loro (to be on top of things). Puedes hablar de todo, porque ests al loro de lo que sucede diariamente. You can talk about everything, because youre on top of everything that happens daily. estar a oscuras (to be ignorant or in the dark). Estoy a oscuras en estos temas. I am in the dark about these subjects. estar a punto de (to be on the verge of). Estaba a punto de llamarte. I was just about to call you. estar al corriente (to be up to date or current). No estoy al corriente en mis pagos. Im not up to date with my payments. estar al dà ­a (to be informed). Quiero estar al dà ­a con todo lo que pueda con mi bebà ©. I want to know about everything that can happen with my baby. estar al là ­mite (to be at ones limit in patience). En estos momentos estoy al là ­mite, y me hace daà ±o ver como mi novio se autodestruye. These days I am at my limit, and it pains me to see how my boyfriend is self-destructing. estar de buen nimo (to be in a good mood). Mariano explicà ³ que ayer su padre estuvo de buen nimo. Mariano explained that yesterday his father was in a good mood. estar de ms (to be excessive). La seguridad nunca est de ms durante la presencia del presidente. There is never too much security during the presence of the president. estar mal de (un à ³rgano del cuerpo) (to have a bad body part). Roger estaba mal de la espalda y no podà ­a jugar con toda su capacidad. Roger had a bad back and couldnt play to full capacity. estar por ver (to remain to be seen). Y est por ver la respuesta del Gobierno de Espaà ±a. The response of the Spanish government remains to be seen. estar sin un cobre, estar sin un duro (to be broke). Recuerdo una à ©poca que yo estaba sin un duro. I remember a time when I was flat broke. estar visto (to be obvious). Estaba visto que no era particularmente una buena opcià ³n. It was obvious that it wasnt particularly a good option. llegar a estar (to become).  ¿Cà ³mo llegaste a estar delgada tan rpido? How did you become thin so quickly? Sources: Sample sentences have been adapted from online sources that include es.Gizmodo.com, Carlos Soriano Gà ³mez, Fobiasocial.net, Foro de Ayuda Psicolà ³gica, Correo del Orinoco, es.Yahoo.com, ComoHacerPara.com, ElBebe.com, ElDà ­a.es, BioBioChile, D. Vzquez Molini and Informe21.com.

Critically discuss the nursing paradigms that you consider have the Essay

Critically discuss the nursing paradigms that you consider have the most relevance to nursing and to your own clinical practice - Essay Example to develop a strong interpersonal relationship with the patient and give quality and compassionate care for optimum positivism for the patient in particular. According to Polit and Hungler (2006) paradigm is a "way of looking at natural phenomena that encompasses a set of philosophical assumptions and that guides ones approach to inquiry" (pg. 183). Nurses naturally use this type of thinking in their practice to assist them in determining what the best care methods are going to be for a patient. Of course this thought moves into the usage of metaparadigms in the field as well, with both interlacing together to form a unified pattern in professional nursing. A Metaparadigm differs from a nursing paradigm as, â€Å"it is known as a group of statements identifying a relevant phenomena† (Fawcett 1984, pg. 84). The Metaparadigm model has four known concepts that directly affect the clinical practice of any nurse, regardless of this is in theater or outside on the surgical ward, or even on a basic ward. These four known central concepts that directly affect the discipline of nursing are as follows: Carper’s Pattern of Knowing (1995) intertwines with this mental train of thought in nursing because it moves beyond the technical aspects of the field and goes more into personal knowledge and experiences. This is explicably true in the area of understanding the patient’s direct needs and the environment from which they came from before ending up in the medical environment (Sorrell & Sorrell 1995, pg. 2). It is also true that this type of philosophy, while bringing many nursing ideas into a more unified spectrum has also brought in a paramount shift in the profession itself. According to how Sorrell & Sorrell (1995) analyzed this concept in their research, they show how Carper believes that every knowledgeable pattern in nursing must be fully understood so that a perfect type of congruence between all of the theorizations and concepts will develop and not be

Executive summary for a project Case Study Example | Topics and Well Written Essays - 250 words

Executive summary for a project - Case Study Example tified that the core weakness within the replenishment process is delay time where delays at the bottleneck are longer: the time taken in completing the critical activities such as assembling of the required merchandise to be taken to the stores, or ordering of the required merchandise from the suppliers to fulfil market demand (longer lead time). In most instances a FIFO discipline most likely have higher delay time and lower outflow rates even in the best case scenario where there is regularity in processing of the merchandise. Such impact constrains the output rate at the bottleneck. The core solutions derived from the problem analysis to develop a â€Å"To-Be† replenishment process aimed at increasing operational excellence includes: Optimising lead time through adoption of just in time technique; the selection of a few strategic and trusted suppliers for whom a strategic partnership is made and the company’s replenishment process is integrated into such supplierâ⠂¬â„¢s systems; Vendor managed Inventory system which give control to the suppliers and ensures effective flow of accurate information on the level of merchandise required, which can be enhanced through incorporation of radio frequency Identification (RFID) system in the products; and cross docking where products are transported directly from the suppliers to the stores with the merchandise undergoing little to nil handling. Attaining operational excellence is critical for any business as organisations cannot afford to have quality issues, high cost operations or even long market cycles (Oracle 3). Notably, one of the core advantages that businesses often attain to achieve is effective inventory management to not only ensure high quality fresh products but also lower costs. Optimal inventory management is vital for any business organisation. The core benefits of having a much leaner inventory includes reduction in operation costs, higher customer satisfaction, and increased sales. In deed Lee (1)

Week 4 Individual Assignment Essay Example | Topics and Well Written Essays - 1250 words

Week 4 Individual Assignment - Essay Example Clear Hear manufactures phones at its own facilities. One of the goals of the managers of the company is to optimize production in order to take advantage of idle capacity. The company has an unused production capacity of 70,000 units. The firm has to decide whether or not to take an order of 100,000 units. The current bid is a price of $15 per unit. The firm has to consider the variable and fixed cost of producing the model. Clear Hear produces two types of phone models. The Alpha model is sold at $20. The profit margin on this model is 15% due to the fact that total cost equal $17 per unit. The Beta model is sold at $30 and it has a net market of 26.66%. Due to the fact that the production cost are higher than the price bid of the proposal the company cannot take the order under normal circumstances. To take the order the firm has to outsource the order to produce the phones at $14. The company would make a profit of $100,000 on the transaction. In order to increase revenues Clear Hear can utilize several strategies. The firm can invest money in marketing in order to attract new customers. Advertising campaigns can ignite the demand of the product. Another way to improve revenues is by motivating the sales staff. Increasing commission incentives is a way to motivate the salespeople to produce more. A firm can increase its production capacity by investing in technology such as new machinery for the production line. Increasing the production capacity of the firm can enabled the company to shift its supply curve to the right. Greater production would enable the company to increase its revenues. Another simply solution to increase the demand for the product is to decrease the price of the phones. Due to the thin margin on the Alpha model the company has to be careful with its price decreases because it may hurt profitability. It is important to pay attention to the laws of diminishing return.

Serum-hepatocyte Growth Factor (S-HGF) in Diagnosis of SPNs

Serum-hepatocyte Growth Factor (S-HGF) in Diagnosis of SPNs Value of hepatocyte growth factor in the differential diagnosis of solitary pulmonary nodules[F1] Haixin Yu, Yan Wang*, Wenduan Ma, Haixiang Yu, Shengtao Shang Abstract Purpose: To evaluate serum-hepatocyte growth factor (S-HGF) in the differentiation of solitary pulmonary nodules(SPNs)[F2].[F3] Methods: The study comprised 42 serum samples from SPN patients and 10 healthy samples as control. The HGF was measured by the commercially available immunoassay[F4].[F5] Serum levels of HGF of 42 patients with SPN was measured by ELISA kit, and compared with the control group of 10 normal subjects. The nodules were diagnosed by operation and pathology. Results: The median level of S-HGF was 180( range from 100 to 300) pg/ ml in the healthy control group, 165( range from 100 to 400) pg/ ml in benign SPNs group and while 395( range from 100 to 1550) pg/ ml in malignant SPNs group, The S-HGF mean level of malignant group was significantly higher than the with significant difference observed between the malignant group and control group(P. Moreover, the malignant group was also significantly higher than the , and between the malignant group and the benign group(Pwhile no significant difference between the benign , but not between the benign group and the control group(Pà ¯Ã‚ ¼Ã… ¾0.05). Furthermore, the S-HGF was also shown no statistically significant difference was observed(Pà ¯Ã‚ ¼Ã… ¾0.05) in different pathologic types of the limited number of lung cancer patients.In addition, when S-HGF in different pathologic types of the limited number of lung cancer patients were compared, no statistically significant difference was observed (Pà ¯Ã‚ ¼Ã… ¾0.05). Conclusion: S-HGF is valuable in the differential diagnosis of solitary pulmonary nodules. It was suggest that the patients with SPNs should consider an operation when the S-HGF level ≠¥250pg/ml, and malignant SPNs are highly suspected while S-HGF level ≠¥400pg/ml, surgical intervention should be taken immediately.S-HGF is valuable in the differential diagnosis of solitary pulmonary nodules. An elevated S-HGF level≠¥250pg/ml in patients with SPNs may strongly speak for malignant nodules and operation is suggested. If S-HGF level ≠¥400pg/ml, malignant SPNs are highly suspected, active surgical intervention should be taken. Key words: diagnosis, hepatocyte growth factor, solitary pulmonary nodule, NSCLClung cancer 1. Introduction The solitary pulmonary nodules (SPNs) is a single mass in the lung less than or equal to 3 cm in diameter, without concomitant pneumonia and atelectasis of involved lung segments and lobes [1]. In the general population, it’s reported that approximately 5% of SPN patients show lung cancer by radiology [2], which is considered one of the most common forms of cancer with a high death incidence ratio in the world [3]. Diagnoses of benign and malignant SPN has been concerned and become a challenge in these decades [4, 5]. Therefore, it is utmost important to improve the method in the characterization of SPNs[6].   With the development of modern medical science and technology, several detecting and monitoring method were used in screening the SPNs and lung cancer [2, 7, 8], Momen[9] et al. have compared three detection methods for identifying malignant SPNs for the sensitivity and specificity. The positron emission tomography (PET) imaging was consistently higher (80 to 100%) for its sensitivity, while was with lower specificity and larger variation (40 to 100%). Also, they found the similar results in dynamic CT with enhancement (sensitivity, 98 to 100%; specificity, 54 to 93%). In studies of CT-guided needle biopsy, sensitivity and specificity performed excellent, but nondiagnostic results were seen approximately 20%. Dalli[8] et al. also showed the similar result in 2013. While Carsten[10] et al. suggested that routine flexible bronchoscopy should be included in the pre-operative work-up of patients with SPNs in his study. Even so, it seems to find a better detection method of long cancer an d characterization of SPNs is still necessary. Serum-hepatocyte growth factor (S-HGF, Serum-HGF) is an important fibroblast-secreted protein that mediates development and progression of cancers[11]. Nagio et al. [12] gave the evidence that the S-HGF levels of patients with small cell lung cancer (SCLC) were significantly higher than those of patients with benign SPNs and healthy subjects. Ujiie et al[13] had proved that the levels of HGF in serum could be used as prognostic indicators of the patients with stage III non-small cell lung cancer (NSCLC) undergoing surgery and chemotherapy. Kasahara et al. [14] found that higher HGF levels were significantly associated with a shorter progression-free survival (PFS) and overall survival (OS) in patients with non-small cell lung adenocarcinoma. The expression level of S-HGF could be a sensitive indicator and an independent biomarker for evaluating the therapeutic effects and the prognosis in patients with lung cancer. Therefore, we give the hypothesis that S-HGF may be a potential targ et in diagnoses of benign and malignant SPNs associated with lung cancer. In our study, we used Enzyme linked immunospot assay (ELISA) method to detect the S-HGF levels between different serum samples from SPNs patients and healthy subjects. The solitary pulmonary nodule(SPN) is defined as a round opacity ≠¤3 cm in diameter surrounded by lung parenchyma[1].There should be no associated with hilar lymphadenopathy, atelectasis, pneumonia or chest wall pathologies. With more importance attached to physical examination and the development of medical imaging examination technology, the detection rate of SPN is on the increase. In the general population, approximately 5% of all SPNs shown by radiology are reported to be carcinomas[2]. In eight large trials of lung cancer screening, Momen et al[3] have compared the sensitivity and specificity in three detection methods for identifying malignant SPNs. The sensitivity of PET imaging was consistently high (80 to 100%), whereas specificity was lower and more variable (40 to 100%). They found similar results in dynamic CT with enhancement(sensitivity, 98 to 100%; specificity, 54 to 93%).In studies of CT-guided needle biopsy, sensitivity and specificity were excellent, but nondiagnostic results were seen approximately 20% of the time. Carsten et al[4], in a study of 225 patients with SPN of unknown origin, observed that the bronchoscopic biopsy results were positive in 84(46.5%) patients with lung cancer. The differential diagnosis between malignant and benign solitary pulmonary nodules (SPNs) is always a difficult point in clinical practice. In this study, we inv estigate the clinical significance of the serum level of hepatocyte growth factor(HGF) in patients with SPNs. 2. Methods 2.1. Patients According to the definition, inclusion criteria was setà ¯Ã‚ ¼Ã… ¡Ãƒ ¯Ã‚ ¼Ã‹â€ 1à ¯Ã‚ ¼Ã¢â‚¬ °On computed tomography (CT), SPN is a round opacity ≠¤3 cm in diameter surrounded by lung parenchyma.à ¯Ã‚ ¼Ã‹â€ 2à ¯Ã‚ ¼Ã¢â‚¬ °There should be no associated with hilar lymphadenopathy, atelectasis, pneumonia or chest wall pathologies.à ¯Ã‚ ¼Ã‹â€ 3à ¯Ã‚ ¼Ã¢â‚¬ °Regardless of age and gender. In consideration of some influences, exclusion criteria was setà ¯Ã‚ ¼Ã… ¡(1)Inflammation or infection within a month. (2)Surgery or trauma within 6 months. (3)Various liver diseases. (4)Chronic renal failure. (5)Arteriosclerosis. (6)Rheumatoid arthritis and osteoarthritis. (7)Diabetes mellitus. The case group included 42 patients with SPNs, mean age 60.7 years (range, 42 to 72). Besides, 10 healthy adult subjects were chosen as control. 2.2. Specimen collection The morning fasting venous blood of all subjects was collected in sterile polypropylene tubes, containing ethylenediamine tetraacetic acid (EDTA), and immediately centrifuged at 400rpm for 10min. Then, the plasma was stored at -70 °C until the assays were performed. 2.3. Assay for S-HGF We used Sandwich enzyme-linked immunosorbent assay(ELISA) to measure S-HGF. The HGF monoclonal antibody and standard substance for the assays were purchased from American RD systems. Goat-anti-human HGF polyclonal antibody as the primary antibody and donkey-anti-goat IgG polyclonal antibody labeled with horseradish peroxidase as the secondary antibody were both purchased from British biotech company Abcam. 2.4. Pathological diagnoses All the 42 patients with SPNs were pathological diagnosed postoperatively. 12 cases were benign nodules(4/12 were tuberculoma, 6/12 were inflammatory pseudotumor, 2/12 were hamartoma) and 30 cases were malignant nodules(17/30 were adenocarcinoma, 13/30 were squamous carcinoma). 2.5. Statistical methods All data were analyzed by SPSS 19.0. Because the measured data manifested as skewed distribution, geometrical mean Gà ¯Ã‚ ¼Ã‹â€ logG ±sà ¯Ã‚ ¼Ã¢â‚¬ °was calculated in each group after logarithmic transformation had been carried out on each datum. Then, Students t test was performed on both sides. Differences were considered statistically significant at Pà ¯Ã‚ ¼Ã…“0.05. 3. Result The S-HGF data measured of healthy control group, benign SPNs group and malignant SPNs group is shown in Table 1Table 1 are the measured S-HGF data of healthy control group, benign SPNs group and malignant SPNs group. All the data manifest as skewed distribution(All Pà ¯Ã‚ ¼Ã…“0.05). Geometrical mean Gà ¯Ã‚ ¼Ã‹â€ logG ±sà ¯Ã‚ ¼Ã¢â‚¬ °was calculated in each group after logarithmic transformation had been carried out on each datum(Table 2). TABLE 1 The S-HGF levelà ¯Ã‚ ¼Ã‹â€ pg/mlà ¯Ã‚ ¼Ã¢â‚¬ ° of healthy control group, benign SPNs group and malignant SPNs group. TABLE 2 The comparison of S-HGF level of each group after logarithmic transformation had been carried out on each datum. aBenign SPNs group vs healthy control group, Pà ¯Ã‚ ¼Ã… ¾0.05 bMalignant SPNs group vs healthy control group, Pà ¯Ã‚ ¼Ã…“0.05 cMalignant SPNs group vs benign SPNs group, Pà ¯Ã‚ ¼Ã…“0.05 The S-HGF level of benign SPNs group compared with the healthy control group, there were no significant differences (Pà ¯Ã‚ ¼Ã… ¾0.05). The S-HGF levels of malignant SPNs group were significantly higher than those of healthy control group(Psignificant differences (Pà ¯Ã‚ ¼Ã… ¾0.05, Table 3). TABLE 3 The comparison of S-HGF level of adenocarcinoma and squamous carcinoma aSquamous carcinoma vs adenocarcinoma, Pà ¯Ã‚ ¼Ã… ¾0.05 4. Discussion Hepatocyte growth factor/scatter factor (HGF/SF) from the serum of hepatectomized rats was first partially purified and described by Nakamura in 1984[15]. HGF receptor encoded by the c-met proto-oncogene is a member of the tyrosine kinase class of cell surface receptors. As a kind of cytokine, the hepatocyte growth factor(HGF) has widely biological activities, including regeneration, antifibrosis, cytoprotection, and differentiation[16]. Moreover, HGF is a predominant fibroblast-derived factor that stimulates mitogenesis, motogenesis, and the invasion and metastasis of human carcinoma cells [17]. The growth and metastasis of tumors depend on angiogenesis which is the result of the imbalance of promoters and inhibitors. The S-HGF levels in patients with acute hepatitis, chronic hepatitis and cirrhosis were found to be slightly higher than those in normal subjects[18]. So the patients with various liver and gall diseases were first excluded. So far, some studies showed the S-HGF levels were significantly increased in patients with Inflammation, infection, underwent surgery or trauma. Therefore, the patients with inflammation or infection within a month and the patients underwent surgery or trauma within 6 months were both excluded. Johanna et al. [19] had concluded that patients with chronic renal failure (CRF) have a systemic HGF profile reflecting a chronic inflammatory condition with high concentration, but low biological activity, of HGF. Therefore, the patient samples with CRF were also excluded. The S-HGF levels in patients with arteriosclerosis, rheumatoid arthritis, osteoarthritis, and diabetes mellitus were reported to be significantly higher than that in healthy population. So, the patients with these diseases were excluded as well. Tsao et al.[20] showed the HGF messenger RNA(mRNA) and protein were predominantly expressed by the tumor cells in a high percentage of primary NSCLC. Our study showed serum of the healthy control group contained trace amounts of S-HGF, the S-HGF levels of the patients with benign SPNs were nearly close to the healthy control group(PHGF levels of the patients with malignant SPNs were significantly higher than the healthy control group(Pà ¯Ã‚ ¼Ã… ¾0.05) and the benign SPNs group(Pà ¯Ã‚ ¼Ã… ¾0.05). It illustrated that the high level of S-HGF was associated with lung cancer. And it was further confirmed that S-HGF could be expressed by the carcinoma cells in NSCLC. The S-HGF levels of part of patients with squamous carcinoma in the malignant SPNs group were observed to be higher(à ¯Ã‚ ¼Ã… ¾700pg/ml) and the S-HGF statistical analysis by the statistical difference between the squamous carcinoma group and adenocarcinoma group, for the S-HGF, the median level of the squamous carcinoma group was 370(100-1500)pg/ml while the adenocarcinoma group was 420(100-1550)pg/ml, no statistically significant difference between the two groups(P>0.05). No further conclusions could be made, in case of the number limitation of the samples. The result confirmation should be amortized awaits further research. Further analysis of the 20 patients with high levels of S-HGF(≠¥250pg/ml), there are 3 patients(15%) with benign SPNs and 17 patients(85%) with malignant SPNs. Furthermore, for the 20 patients, the result shows that 1 patients (6.25%) with benign SPNs and 15 patients (93.75%) with malignant SPNs in the 16 patients with high levels of S-HGF(≠¥400pg/ml), It reveals that an elevated S-HGF level ≠¥250pg/ml in patients with SPNs are more likely to be malignant and when the S-HGF level ≠¥400pg/ml, malignant SPNs are highly suspected. Conclusion In conclusion, our study shows significant in the differential diagnosis between malignant and benign solitary pulmonary nodules (SPNs) for the S-FGF assay. The S-HGF levels of malignant SPNs group are significantly higher than the healthy control group(P SPNs group(Pà ¯Ã‚ ¼Ã…“0.05). The differences between benign SPNs group and healthy control group have no statistically significant(Pà ¯Ã‚ ¼Ã… ¾0.05). An elevated S-HGF level ≠¥250pg/ml in patients with SPNs are more likely to be malignant, surgical therapy should be considered. If S-HGF level ≠¥400pg/ml, malignant SPNs are highly suspected, surgical intervention is recommended without delay. Hepatocyte growth factor/scatter factor (HGF/SF) from the serum of hepatectomized rats was partially purified and described by Nakamura for the first time in 1984. HGF receptor encoded by the c-met proto-oncogene is a member of the tyrosine kinase class of cell surface receptors. As a kind of cytokine, the hepatocyte growth factor( HGF) has widely biological activities, including regeneration, antifibrosis, cytoprotection, and differentiation[5]. Moreover, HGF is a predominant fibroblast-derived factor that stimulates mitogenesis, motogenesis, and the invasion and metastasis of human carcinoma cells[6]. The growth and metastasis of tumors depend on angiogenesis which is the result of the imbalance of promoters and inhibitors. Sengupta et al[7] had demonstrated that HGF/SF could induce angiogenesis independently of VEGF, possibly through the direct activation of the Akt and ERKs. The S-HGF levels in patients with acute hepatitis, chronic hepatitis and cirrhosis were found to be slightly higher than those in normal subjects[8]. So the patients with various liver and gall diseases were first excluded. So far, some studies have found the S-HGF levels were significantly increased in patients with Inflammation or infection, or underwent surgery or trauma. Therefore, the patients with inflammation or infection within a month and the patients underwent surgery or trauma within 6 months were both excluded. Johanna et al[9] had concluded that patients with CRF have a systemic HGF profile reflecting a chronic inflammatory condition with high concentration, but low biological activity, of HGF. Therefore, the patients with CRF were also excluded. The S-HGF levels in patients with arteriosclerosis, rheumatoid arthritis, osteoarthritis, and diabetes mellitus were reported to be significantly higher than that in healthy population. So, the patients with these diseases were all excluded. Tsao et al[10] had showed that HGF messenger RNA(mRNA) and protein were predominantly expressed by the tumor cells in a high percentage of primary NSCLC. It indicated in our research that the serum of the healthy control group only contained trace amounts of S-HGF, the levels of S-HGF of the patients with benign SPNs were close to those of the healthy control group(Pà ¯Ã‚ ¼Ã… ¾0.05) and the benign SPNs group(Pà ¯Ã‚ ¼Ã… ¾0.05). It illustrated the fact that high level of S-HGF was associated with lung cancer. And, it was further confirmed that S-HGF could be expressed by the carcinoma cells in NSCLC. In addition, Nagio et al[11] had proved that the levels of S-HGF of patients with SCLC were significantly higher than those of patients with benign SPNs and healthy subjects. The levels of S-HGF of a portion of patients with squamous carcinoma in the malignant SPNs group were observed to be higher(à ¯Ã‚ ¼Ã… ¾700pg/ml) and statistical analysis was conducted to fond the statistical difference of S-HGF between the squamous carcinoma group and the adenocarcinoma group. The S-HGF median of the squamous carcinoma group was 370(100-1500)pg/ml and the adenocarcinoma group was 420(100-1550)pg/ml, no statistically significant difference was found between the two groups(P>0.05). No firm conclusions could be made, possibly due to the limited number of cases. It is of concern and remains to be further studied. Further analysis was taken in 20 patients with high levels of S-HGF(≠¥250pg/ml), 3 patients(15%) had benign SPNs and 17 patients(85%) had malignant SPNs. Further observation was made, among the 20 patients, there were 16 patients with high levels of S-HGF(≠¥400pg/ml), 1 patients(6.25%) had benign SPNs and 15 patients(93.75%) had malignant SPNs. It reveals that an elevated S-HGF level ≠¥250pg/ml in patients with SPNs are more likely to be malignant and if S-HGF level ≠¥400pg/ml, malignant SPNs are highly suspected. Ujiie et al[11] had proved that the levels of HGF in serum could be useful prognostic indicators of the survival of patients with stage III NSCLC undergoing surgery and chemotherapy. Kasahara et al[12] had shown that higher HGF levels were significantly associated with a shorter progression-free survival (PFS) and overall survival (OS) in patients with non-small cell lung adenocarcinoma. The expression level of S-HGF could be a sensitive indicator and an independent judgement standard for evaluating the therapeutic effects and the prognosis in patients with lung cancer. Furthermore, understanding the role of HGF in the tumor progression may help in designing new therapeutic strategies for lung cancer. In conclusion, the assay for S-HGF may be of some significance in the differential diagnosis between malignant and benign solitary pulmonary nodules(SPNs). The S-HGF levels of malignant SPNs group were significantly higher than those of healthy control group(Pà ¯Ã‚ ¼Ã…“0.05). The differences between benign SPNs group and healthy control group had no statistically significant(Pà ¯Ã‚ ¼Ã… ¾0.05). An elevated S-HGF level ≠¥250pg/ml in patients with SPNs are more likely to be malignant, surgical therapy should be suggested. If S-HGF level ≠¥400pg/ml, malignant SPNs are highly suspected, active surgical intervention should be taken. References 1.  Hansell, D.M., et al., Fleischner Society: glossary of terms for thoracic imaging. Radiology, 2008. 246(3): p. 697-722[à ¥Ã‚ ¼Ã‚  Ãƒ ¨Ã¢â‚¬ ¹Ã‚ ±Ãƒ ¥Ã‚ ½Ã‚ ª13]. 2.  Klein, J.S. and M.A. Zarka, Transthoracic needle biopsy: an overview. J Thorac Imaging, 1997. 12(4): p. 232-49. 3.  Siegel, R., D. Naishadham, and A. Jemal, Cancer statistics. CA Cancer J Clin, 2012. 62(1): p. 10-29. 4.  Cao, C., et al., A meta-analysis of unmatched and matched patients comparing video-assisted thoracoscopic lobectomy and conventional open lobectomy. Ann Cardiothorac Surg,2012. 1(1): p. 16-23. 5.  Zhan, P., Q. Qian, and L.K. Yu, Prognostic value of COX-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis. J Thorac Dis, 2013. 5(1): p. 40-7. 6.  Tong, X., et al., [Clinical experience of the treatment of solitary pulmonary nodules with da vinci surgical system]. Zhongguo Fei Ai Za Zhi, 2014. 17(7): p. 541-4. 7.  Aberle, D.R., et al., Results of the two incidence screenings in the National Lung Screening Trial. N Engl J Med, 2013. 369(10): p. 920-31. 8.  Dalli, A., et al., Diagnostic value of PET/CT in differentiating benign from malignant solitary pulmonary nodules. J BUON, 2013. 18(4): p. 935-41. 9.  Wahidi, M.M., et al., Evidence for the treatment of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition). Chest, 2007. 132(3 Suppl): p. 94S-107S. 10.  Schwarz, C., et al., Value of flexible bronchoscopy in the pre-operative work-up of solitary pulmonary nodules. Eur Respir J, 2012. 41(1): p. 177-82. 11.  Ma, D.C., et al., [Hepatocyte growth factor did not enhance the effects of bone marrow-derived mesenchymal stem cells transplantation on cardiac repair in a porcine acute myocardial infarction model]. Zhonghua Xin Xue Guan Bing Za Zhi, 2006. 34(2): p. 119-22. 12.  Takigawa, N., et al., Serum hepatocyte growth factor/scatter factor levels in small cell lung cancer patients. Lung Cancer, 1997. 17(2-3): p. 211-8. 13.  Ujiie, H., et al., Serum hepatocyte growth f

The Worst Jobs in the World :: essays research papers

The Worst Jobs in the World TURD DIVER - cleans the grate at the sewer treatment plant HOG SLAUGHTERHOUSE PROCESSOR - I work in a slaughterhouse where we process hogs. They come in by the truckload and sometimes I have to lead them to the killing pen and kill them with a bullet in the head. Usually this job means that the technician ends up covered with blood. The hog is then placed upon meat hooks by its hind legs. After the hog is lifted into position, its neck is slit so that blood can drain into a large vat. Sometimes it seems that gallons of blood pours out. One benefit, though, is cheap hams and bacon. We get to buy meat at very low cost. Too bad we don't make enough money to buy very much. $9.00 as processor. It's a living. BURNT POTATO CHIP PICKER - For minimum wage you get to watch cooked potato chips quickly fly by on a conveyor belt and you have to pick out the burnt ones. This is done in 90+ degree temperature, with a thick coating of oil in the air. With these three ingredients, it isn't long before motion sickness (watching the chips fly by) increases with the smell and temperature causing you to want to barf. And you know how it is having a minimum wage job, you don't get a break and have to keep your nose to the grindstone. Needless to say I turned down overtime. GAY BAR JANITOR - Think about it . . . Cleaning a bar is a bad enough thought. In a gay bar some of the things you see, hear and find can be very confusing and leave you not wanting to touch anything! Ever!!! ARMPIT SNIFFER in a deodorant factory. The World's Worst Jobs - Nuclear Warhead Sensitivity Technician - Circus Elephant Clean Up Specialist - Rotten Sardine Taste Detector - Assistant To The Boss's Nephew - Shark Baiter - Hurricane Photographer - Director Of Public Relations, Chernobyl Nuclear Facility - Prison Glee Club President - Road Kill Removal Crew Worst Jobs 1.Lumberjack 2.Fisherman 3.Cowboy 4.Ironworker 5.Seaman 6.Taxi driver 7.Construction worker 8.Farmer 9.Roofer 10.Stevedore World's Worst Jobs Do you think your job stinks? You could be a Flatus Odor Judge. That's just one of several of the Worst Jobs in Science according to the editors of "Popular Science" magazine, who just compiled the list for the latest issue. Topping the chart for worst jobs are the odor judges at a Minneapolis gastroenterologist -- they're are paid to smell people's farts to determine potentially critical medical symptoms.